What Medications May Cause Lymphoma – Avoid These Common Culprits

Every day, millions of people take medications prescribed to manage chronic conditions.

Relieve pain, or treat autoimmune issues. But what if some of those same medications come with an unexpected and serious risk—one that most patients never hear about from their doctor?

Let’s talk about lymphoma, a type of cancer that begins in the lymphatic system. While the exact causes of lymphoma are still being studied, a growing body of research suggests that certain medications may increase your risk. The connection is often buried in clinical studies or legal settlements—but it’s very real.

The Medications Under Scrutiny

While it’s important to understand that not every person who takes these drugs will develop lymphoma, here are some categories and examples of medications that have raised red flags:

1. Immunosuppressive Drugs

Used in autoimmune conditions like rheumatoid arthritis or after organ transplants, these medications work by weakening your immune system. Unfortunately, that same suppression can allow abnormal lymph cells to multiply unchecked.

Methotrexate

Azathioprine (Imuran)

Cyclosporine

Several studies have linked long-term use of immunosuppressants to increased rates of non-Hodgkin lymphoma.

2. TNF Inhibitors

Medications like Humira (adalimumab), Enbrel (etanercept), and Remicade (infliximab) are biologics used to treat conditions like Crohn’s disease and psoriasis. They’ve revolutionized care—but not without a cost.

In 2009, the FDA issued a black box warning for TNF blockers due to a possible risk of lymphoma in children and young adults.

3. Certain Blood Pressure Medications

Recent lawsuits have alleged links between hydrochlorothiazide, a common diuretic, and a higher risk of skin cancer and lymphoma when taken over long periods.

So, Should You Stop Taking Your Medication?

Absolutely not without talking to your doctor first. The potential risk needs to be weighed against the benefit you’re getting from the medication. But being informed is the first step.

If you’re taking any of the drugs mentioned above—especially over a long period—consider having an honest conversation with your healthcare provider. Ask about:

Routine screenings or blood tests

Alternative treatment options

Your personal risk factors

The Bottom Line

Some medications may carry a hidden risk—but the power to act is in your hands. Understanding which prescriptions have been linked to lymphoma could make all the difference in your long-term health strategy.