In 2025, neurologists are urging patients and caregivers to re-examine the long-term medications they or their loved ones are taking. Here's what you need to know about the prescription drugs that have been linked to Parkinsonism or increased risk of Parkinson’s-like symptoms.
What Is Drug-Induced Parkinsonism?
Unlike classic Parkinson’s disease, which develops gradually due to the loss of dopamine-producing brain cells, drug-induced Parkinsonism is triggered by medications that interfere with dopamine activity.
Symptoms often look identical to Parkinson’s disease:
Shaking hands
Slowness of movement
Muscle stiffness
Balance problems
The difference? In many cases, the symptoms can improve or even disappear when the medication is discontinued.
List of Medications Most Commonly Linked to Parkinson’s Symptoms
Here are the drug types most frequently associated with Parkinson-like effects:
🟥 Antipsychotics
Used to treat schizophrenia, bipolar disorder, and severe depression.
Examples: Haloperidol, Risperidone, Olanzapine
🟨 Antiemetics (Nausea Drugs)
Commonly used for motion sickness or during chemotherapy.
Examples: Metoclopramide (Reglan), Prochlorperazine (Compazine)
🟦 Calcium Channel Blockers
Used for blood pressure and heart rhythm regulation.
Certain types have been associated with motor control side effects.
🟩 Mood Stabilizers & Antidepressants
Some long-term psychiatric meds may reduce dopamine signaling over time.
Who’s at Risk?
Older adults—especially those over 60—are most vulnerable to drug-induced Parkinsonism, often due to slower metabolism and long-term medication use. Women and individuals already prone to neurological issues may also be more sensitive.
What You Should Do If You’re Concerned
Don’t stop medications suddenly. Always consult a doctor before making changes.
Track your symptoms. Document when they started, how they’ve progressed, and which medications changed.
Ask your provider about alternatives. In many cases, newer medications or adjusted dosages can help reduce symptoms.