Nasal polyps are soft, noncancerous growths in the nasal passages or sinuses that can cause congestion, pressure, and recurring infections. Often tied to inflammation or allergies, they make breathing difficult—but new treatments are changing that. From advanced biologics to minimally invasive procedures, here are the top 5 trending nasal polyp treatments in 2025.
1. Biologic Therapies (Monoclonal Antibodies)
Why it’s trending:
Biologics are one of the biggest breakthroughs in treating nasal polyps—especially for people with chronic rhinosinusitis with nasal polyps (CRSwNP) and coexisting asthma.
Popular options include:
Dupilumab (Dupixent) – FDA-approved for nasal polyps, it reduces inflammation by blocking specific immune pathways (IL-4 and IL-13).
Omalizumab (Xolair) – Often used for allergic asthma, it’s also showing promise in reducing nasal polyp size and symptoms.
Benefits:
Non-surgical option
Reduces recurrence and inflammation
Improves smell, airflow, and sinus health
2. Nasal Steroid Sprays with Improved Delivery
Why it’s trending:
Steroid nasal sprays have long been used to shrink polyps, but newer delivery systems—like exhalation-delivered fluticasone (Xhance)—are making them more effective than ever.
How it works:
Instead of a typical spray, Xhance uses your own breath to deliver medication deep into the sinus cavities.
Benefits:
Targets inflammation directly
Less systemic exposure than oral steroids
Fewer side effects, more localized relief
3. Balloon Sinuplasty (Minimally Invasive Procedure)
Why it’s trending:
Balloon sinuplasty is gaining popularity as a quick, minimally invasive solution for patients with recurring nasal polyps and sinus blockage.
How it works:
A small balloon is inserted into the sinus passages and gently inflated to open up blocked areas—restoring drainage and airflow.
Benefits:
In-office procedure
No incisions or tissue removal
Fast recovery and symptom relief
Often combined with polyp removal for long-term results
4. Low-Dose Oral Corticosteroid Bursts
Why it’s trending:
Oral corticosteroids like prednisone have been used for years to reduce polyp size, but low-dose, short-term bursts are now being used more strategically—especially before biologic treatments or surgery.
Benefits:
Rapid symptom relief
Restores sense of smell in many patients
Often used to “reset” inflammation before long-term therapies
Caution:
Not ideal for long-term use due to potential side effects (weight gain, mood changes, immune suppression).
5. Endoscopic Sinus Surgery with Image Guidance
Why it’s trending:
For severe or recurring nasal polyps that don’t respond to medication, functional endoscopic sinus surgery (FESS) remains the gold standard—now enhanced with image-guided systems that improve precision and safety.
How it works:
A small camera and instruments are inserted through the nostrils to remove polyps and open blocked sinuses, often under real-time navigation.
Benefits:
Removes polyps and restores sinus drainage
Enhances medication effectiveness post-surgery
Now less invasive, with faster recovery thanks to image-guided tools