Nasal polyps are soft, noncancerous growths in the nasal passages or sinuses that can cause congestion, pressure, and recurring infections. Often tied to inflammation or allergies, they make breathing difficult—but new treatments are changing that. From advanced biologics to minimally invasive procedures, here are the top 5 trending nasal polyp treatments in 2025.
1. Biologic Therapies (Monoclonal Antibodies)
Why it’s trending:
Biologics are one of the biggest breakthroughs in treating nasal polyps—especially for people with chronic rhinosinusitis with nasal polyps (CRSwNP) and coexisting asthma.
Popular options include:
Dupilumab (Dupixent) – FDA-approved for nasal polyps, it reduces inflammation by blocking specific immune pathways (IL-4 and IL-13).
Omalizumab (Xolair) – Often used for allergic asthma, it’s also showing promise in reducing nasal polyp size and symptoms.
Benefits:
Non-surgical option
Reduces recurrence and inflammation
Improves smell, airflow, and sinus health
2. Nasal Steroid Sprays with Improved Delivery
Why it’s trending:
Steroid nasal sprays have long been used to shrink polyps, but newer delivery systems—like exhalation-delivered fluticasone (Xhance)—are making them more effective than ever.
How it works:
Instead of a typical spray, Xhance uses your own breath to deliver medication deep into the sinus cavities.
Benefits:
Targets inflammation directly
Less systemic exposure than oral steroids
Fewer side effects, more localized relief
3. Balloon Sinuplasty (Minimally Invasive Procedure)
Why it’s trending:
Balloon sinuplasty is gaining popularity as a quick, minimally invasive solution for patients with recurring nasal polyps and sinus blockage.
How it works:
A small balloon is inserted into the sinus passages and gently inflated to open up blocked areas—restoring drainage and airflow.
Benefits:
In-office procedure
No incisions or tissue removal
Fast recovery and symptom relief
Often combined with polyp removal for long-term results
4. Low-Dose Oral Corticosteroid Bursts
Why it’s trending:
Oral corticosteroids like prednisone have been used for years to reduce polyp size, but low-dose, short-term bursts are now being used more strategically—especially before biologic treatments or surgery.
Benefits:
Rapid symptom relief
Restores sense of smell in many patients
Often used to “reset” inflammation before long-term therapies
Caution:
Not ideal for long-term use due to potential side effects (weight gain, mood changes, immune suppression).
5. Endoscopic Sinus Surgery with Image Guidance
Why it’s trending:
For severe or recurring nasal polyps that don’t respond to medication, functional endoscopic sinus surgery (FESS) remains the gold standard—now enhanced with image-guided systems that improve precision and safety.
How it works:
A small camera and instruments are inserted through the nostrils to remove polyps and open blocked sinuses, often under real-time navigation.
Benefits:
Removes polyps and restores sinus drainage
Enhances medication effectiveness post-surgery
Now less invasive, with faster recovery thanks to image-guided tools
Understanding the Role of Allergens in Nasal Polyps
Allergens can significantly contribute to the development and exacerbation of nasal polyps, especially in those with underlying allergic rhinitis. Pollen, dust mites, pet dander, and mold are common triggers that may lead to chronic inflammation in the nasal passages. This inflammation can create an environment conducive to polyp formation. Identifying and managing these allergens through avoidance strategies or immunotherapy can be crucial for individuals prone to nasal polyps. By minimizing exposure to these irritants, patients often experience fewer symptoms and require less intensive treatment, highlighting the importance of comprehensive allergy management.
Nasal Polyps and Their Impact on Quality of Life
The impact of nasal polyps extends beyond physical symptoms, significantly affecting patients' quality of life. Many individuals report difficulties in daily activities due to congestion, loss of smell, and sleep disturbances caused by nasal obstruction. These issues can lead to chronic fatigue, irritability, and social withdrawal. The emotional toll can be substantial, as individuals may feel frustrated or helpless in managing their symptoms. Addressing nasal polyps effectively not only alleviates physical discomfort but also enhances overall well-being, enabling individuals to engage more fully in social, professional, and personal aspects of life.
Lifestyle Changes to Manage Nasal Polyps Effectively
In addition to medical treatments, certain lifestyle changes can significantly help in managing nasal polyps. Staying hydrated is essential, as proper hydration can help thin mucus and promote sinus drainage. Regular exercise can boost immune function and improve overall respiratory health. Additionally, using a humidifier in dry environments can keep the nasal passages moist, reducing irritation. A balanced diet rich in antioxidants and omega-3 fatty acids may also support anti-inflammatory processes in the body. Implementing these lifestyle adjustments, alongside medical interventions, can lead to more sustainable symptom relief and enhance overall health.
The Importance of Regular Follow-Up with Healthcare Providers
Regular follow-up appointments with healthcare providers are crucial for individuals with nasal polyps, particularly those undergoing treatment. These check-ins allow for the monitoring of polyp size and symptoms, ensuring that treatment plans remain effective. Providers can assess the need for adjustments in medication or therapy, potentially preventing complications or worsening of the condition. Furthermore, ongoing communication fosters a better understanding of the disease, empowering patients to manage their symptoms proactively. Engaging in shared decision-making during these visits can lead to more personalized care and improved outcomes.
Emerging Research in Nasal Polyp Treatment
Research into nasal polyp treatment is evolving rapidly, with studies exploring novel therapies and treatment pathways. Investigations into new biologic agents are underway, targeting different inflammatory pathways involved in polyp formation. Additionally, researchers are examining the genetic factors that may predispose individuals to develop nasal polyps, aiming to identify potential biomarkers for personalized treatments. Clinical trials are also focusing on combination therapies that could enhance the efficacy of existing treatments. As this field advances, patients can expect more tailored, effective options for managing nasal polyps, ultimately improving their health outcomes.