Most women are aware of the traditional breast cancer risk factors—family history, genetics, age. But in 2025, experts are sounding the alarm on a less discussed but potentially serious risk: prescription medications.
What the Research Shows in 2025
Recent studies suggest that long-term use of specific drugs may impact hormone regulation, immune function, or DNA repair pathways—all of which can play a role in the development of breast cancer.
This doesn’t mean these drugs cause cancer directly in every case—but it does mean there is enough evidence for increased caution and personalized medical decisions.
Medications Most Commonly Associated With Breast Cancer Risk
🟥 Hormone Replacement Therapy (HRT)
Particularly combined estrogen-progestin therapy. Long-term use has been tied to higher breast cancer incidence.
🟨 Certain Birth Control Pills
Some studies have linked long-term use of high-dose hormonal contraceptives to increased risk, especially if started at a young age.
🟦 Antipsychotics
Certain medications may elevate prolactin levels, a hormone linked to breast tissue growth.
🟩 Immunosuppressive Drugs
Often used after organ transplants or for autoimmune disorders. They may slightly increase cancer risk due to weakened immune surveillance.
🟫 Antidepressants (Some SSRIs and TCAs)
While not conclusive, some studies suggest a correlation between long-term antidepressant use and breast density changes—a known risk marker.
What Should Women Do?
✔ Don’t panic—but don’t ignore it.
You should never stop a prescribed medication without consulting your doctor.
✔ Ask your provider to review your current list.
Bring up any family history of cancer, and ask if safer alternatives exist.
✔ Schedule regular screenings.
Annual mammograms and breast exams are even more crucial if you’re on one of these medications long-term.