Ozempic quickly gained fame in 2024 for its rapid weight loss results. Along with its popularity came some serious concerns: side effects, shortages, and sky-high costs. In 2025, there are now several alternativesāboth prescription and over-the-counterāthat are safer, more accessible, and more affordable.
Over The Counter Alternatives To Ozempic
š 1. Rybelsus (Oral Semaglutide)
Same active ingredient as Ozempic, but taken as a once-daily pill
Easier to manage than injections
Fewer reported gastrointestinal side effects for some users
Often more insurance-friendly
šæ 2. Berberine Supplements
Natural compound shown to regulate blood sugar and insulin sensitivity
Popular among holistic practitioners as āNatureās Ozempicā
Can aid in weight management without harsh effects
Available over-the-counter and more budget-friendly
š§¬ 3. Mounjaro (Tirzepatide)
A newer prescription med that targets two hunger-related hormones (GIP and GLP-1)
Some trials show greater weight loss than Ozempic
May have different side effect profiles for certain patients
FDA fast-tracked for weight loss approval
š½ 4. GlucoBalance Pro (Non-Rx Supplement)
A blend of fiber, chromium, bitter melon, and cinnamon
Aims to help control appetite and stabilize glucose
Designed as a natural daily support formula
Costs a fraction of prescription meds
š©ŗ 5. Wegovy (Higher-Dose Semaglutide for Weight Loss)
Similar to Ozempic but specifically approved for obesity
Prescribed to non-diabetics who struggle with weight
Must be monitored closely, but effective when paired with lifestyle changes
š§ 6. Carb Control Peptides (Emerging Supplement Trend)
Peptide-based compounds aimed at reducing carb cravings and hunger
Mimic some appetite-suppressing effects without full hormone disruption
Still under study, but gaining popularity in weight loss circles
š 7. Structured Fasting + GLP-1 Activating Foods
Intermittent fasting protocols + foods like chia, citrus, and fermented veggies
Naturally help your body produce GLP-1 (the same hormone Ozempic boosts)
Cost-effective and safe for long-term use
Growing movement among health-conscious adults avoiding injections