Feeling exhausted lately — even after a full night’s sleep? You’re not alone. Millions of people chalk up their fatigue to age, stress, or poor sleep habits… but the real cause might be hiding in your medicine cabinet.
1. Antihistamines (Like Benadryl and Cetirizine)
Originally designed to fight allergies, first-generation antihistamines like diphenhydramine (Benadryl) can cause extreme drowsiness. Even some “non-drowsy” options may build up in your system and leave you feeling foggy.
Tip: Try newer-generation, non-sedating antihistamines — and take them in the evening if fatigue is an issue.
2. Beta Blockers (For Blood Pressure or Heart Issues)
These heart meds, such as metoprolol or atenolol, slow your heart rate to reduce blood pressure — but they can also drain your stamina and energy, especially during physical activity.
Tip: Talk to your doctor about alternative blood pressure meds or adjusting your dosage if you’re noticing chronic fatigue.
3. Antidepressants (Especially SSRIs and Tricyclics)
Ironically, some medications used to treat depression can make fatigue worse. Tricyclics like amitriptyline are known for their sedating effects, while SSRIs can blunt your overall energy.
Tip: Timing matters — and switching to a more activating antidepressant might help. Never adjust dosage without medical advice.
4. Pain Medications (Opioids and Some NSAIDs)
From prescription painkillers like hydrocodone to over-the-counter relief like ibuprofen, many pain relievers can cause drowsiness — particularly when taken frequently.
Tip: Look into non-drowsy pain relief options, and watch for interactions if you’re taking more than one sedating med.
5. Sleep Aids and Anti-Anxiety Meds (Like Xanax or Ambien)
Here’s the paradox: Medications meant to help you rest can leave you feeling sluggish the next day. Benzodiazepines and certain sleep drugs can cause a “hangover” effect — especially in older adults.
Tip: Natural sleep solutions or short-term use only are best. Long-term use can worsen fatigue and brain fog.